While rue has been used for centuries for both culinary and medicinal purposes, as well as in general use as a strewn herb to discourage pests, many modern herbalists suggest that it should not be taken internally. Madame Grieve notes that rue is "strongly stimulating and antispasmodic" and when used in an infusion, acts as an emmenagogue.* However, rue can have toxic or emetic effects if taken in high quantities or immediately after eating.*

Because of its antispasmodic action, rue may be helpful in treating persistant coughs and to reduce flatulence.* Grieve also indicates a strong decoctions of the herb be used topically (on the chest) for bronchitis.* The fresh leaves, applied topically, have a rubefacient effect, and have been used to treat sciatic pain and headaches.*